Watch a comic in action. He acts confident, sure of himself, sure of the audience. His joke is quick. He doesn't waste words
Then he looks at his audience, waiting. That pause is the key. It's called "comic timing." It tells the audience he expects an acknowledgment that they share his view of the vagaries of the world. They oblige with laughter.
She can do it too. Watch Chelsea Handler, who wrings laughter out of even the lamest comments just by pausing, posing, and grinning.